Mesothelin-specific CAR-T Cell Therapy with HLA-gated Safety Mechanism S...

 

 In this study a second CAR-blocker binding to HLA unit was expressed simultaneously in the CAR-T cells. 

This prevents CAR-T cells from attacking normal cells. Here is the full text of relevant paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804709/ 

Blocker of LIR: https://www.sciencedirect.com/science/article/pii/S0161589020304880?via%3Dihub